Misfiring mystery on Gen 2 (2008)

Sorry, I'm late here. I too have had this problem for more than 6! I've bought and replaced all coils spark plugs injectors ECU oil and coolant. I too had evap codes that turned out to be the fuel filler neck had rusted holes in it. I replaced that and never had an evap problem again. But the pesky random misfires have been there for nearly the whole 7yrs I've had the car. I know a good bit about cars and can do all my own work but without the right diagnostic tools, I have not been able to figure this one out. Never got around to taking it to Toyota for it. So if anyone finds a solution it would be greatly appreciated. Id also like to note that The front left wheel bearing in this car is BS! I've paid over 700 dollars to have this same wheel bearing replaced like 3 times in my 01. I just bought and 08 Prius and low and behold the front left wheel bearing has the same problem but I'm not about to keep having this thing replaced! I need some solutions! By the way the last time I finally let Toyota replace it and it only lasted about 3 months before it needed replaced again. They charged 345 to replace it.

 

Someone mentioned the filler neck rusting allowing dirty rainwater to get into the gas tank and cause misfires in the 2001 to 2003 year model. My 01 have the same issue but my filler neck also had to be replaced a long time ago but I still have the misfire problem. Another person mentioned his problem was solved by replacing the actual wires to the injectors. I guess they had a short in them due to harsh weathering. I've replaced nearly the whole engine trying to find this problem so the wires will be what I try next. Also for me I actually suspect a compression problem possibly because I have over 350k miles.