Using some tricks I learned from driving my new Prius, I was able to achieve a 29 mpg tank in my fully loaded Odyssey on the family trip earlier this year! Pretty amazing that the fully loaded Odyssey Touring Elite with 4 and their luggage can get this kind of mileage. Best way to get good mileage I found was to not use cruise control and do my best to keep the engine in Eco mode. I'd speed up on downhills (driving with load) and carry the speed as much as I could possible on uphills. Total trip mileage, which includes lots of idling with AC on for pets comfort at frequent stops... I was always sorely disappointed in my 2005 Odyssey Touring's mileage, 20 was the norm on the highway. This 2012 Odyssey does a lot better. Thanks Priuschat for the mileage tips.