SARS-CoV-2 Coronavirus (COVID-19)

you wouldn't get me into an indoor sports event, even with everyone vaccinated.

in fact, i'm rethinking the whole flu thing in regards to public gatherings in the future. the super spreader, er, market, is a bad enough necessity.

 

1 in 4 COVID patients hospitalized while vitamin D deficient die - Israeli study | The Times of Israel

 

I have not been following this thread for a while. For one thing, it seems for most general population I encounter, the pandemic seems to be already a thing of the past. I guess we are entering an Endemic era now.

Just made a booster shot appointment. I just passed the 6 mo from the last Moderna shot. I do not qualify by age, but the CDC list of suggested people who should get a booster shot is wide enough, I think I can qualify. I will see. Moderna 1/2 shots followed by Moderna booster seems to be the most protective combination of the 9 possible boosters shot combination pairs, according to the recent NIH study published preliminary report (not peer-reviewed).

Heterologous SARS-CoV-2 Booster Vaccinations – Preliminary Report | medRxiv

 

The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency | Cellular & Molecular Immunology

 

i have newfound faith in science with these mnra vaccines. i hope they'll be able to adjust fairly quickly to any dangerous variants, but so far, none have shown to be a major problem

 

Good preliminary news!

Source: Antibody-Free Rapid Detection of SARS-CoV-2 Proteins Using Corona Phase Molecular Recognition to Accelerate Development Time - PubMed

. . . Here, we report a synthetic strategy for nanoparticle corona interfaces that enables the molecular recognition of SARS-CoV-2 proteins without any antibody and receptor design. Our nanosensor constructs consist of poly(ethylene glycol) (PEG)-phospholipid heteropolymers adsorbed onto near-infrared (nIR) fluorescent single-walled carbon nanotubes (SWCNTs) that recognize the nucleocapsid (N) and spike (S) protein of SARS-CoV-2 using unique three-dimensional (3D) nanosensor interfaces. This results in rapid and label-free nIR fluorescence detection. . . .​

This would be a game changer as the test results come back in minutes. More study needed and testing but I really like direct detection of the virus.

Bob Wilson

 

Ethylene glycol poisoning: MedlinePlus Medical Encyclopedia

take - in really really teeny doses?

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It is used external to the body as part of test system. A sample from the subject is mixed and IR florescence detected.

Bob Wilson

 

It would be a mistake to mix up ethylene glycol and polyethylene glycol.

The former is car antifreeze and will kill you.

The latter is a commonly available laxative and you may be given like a pound of it, with an instruction sheet, in advance of a colonoscopy. Unless I'm thinking of something else, there has also been some interesting work with it in minimizing nerve damage at injury sites.

 

Polyethylene glycol is also a common food additive.

 

For those somehow feeling compelled to eat these nanosensors, instead of leaving them in the laboratories as intended:

MedlinePlus: Polyethylene Glycol 3350

"Why is this medication prescribed?

Polyethylene glycol 3350 is used to treat occasional constipation. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. It works by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass. ..."

 

Oops, my bad. Never has so much dialogue been stirred from a too quick a read

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Is OK. This is PriusChat and we ran off the *ssholes years ago.

Bob Wilson

 

antidepressant-fluvoxamine-covid-19-treatment

 

From article:

In the group that took the drug, 11% needed hospitalization or an extended ER stay, compared to 16% of those on dummy pills.​

The population study is large enough but the results are not terribly effective. I would like to see another group replicate this study. Science is full of unreproducible reports.

Bob Wilson

 

Also from the article:

"The results, published Wednesday in the journal Lancet Global Health, were so strong that independent experts monitoring the study recommended stopping it early because the results were clear."

In some other studies, this has meant quitting giving anyone the placebo, instead give everyone the drug that works so well.

And:

"The pill, called fluvoxamine, would cost $4 for a course of COVID-19 treatment. By comparison, antibody IV treatments cost about $2,000 and Merck's experimental antiviral pill for COVID-19 is about $700 per course. Some experts predict various treatments eventually will be used in combination to fight the coronavirus."

"The larger project looked at eight existing drugs to see if they could work against the pandemic virus. The project is still testing a hepatitis drug, but all the others — including metformin, hydroxychloroquine and ivermectin — haven't panned out."

 

The latest study suggests that naturally acquired immunity from having survived a covid-19 infection, is not as effective as vaccine-acquired immunity. And by quite a wide margin.


The Hill: CDC study: Vaccination offers better protection than previous COVID-19 infection

"A new study from the Centers for Disease Control and Prevention (CDC) finds that vaccination provides better protection against hospitalization with COVID-19 than a previous infection with the virus.

The analysis found people hospitalized with coronavirus-like symptoms were more than five times more likely to test positive for COVID-19 if they had had recent prior infection than if they were recently vaccinated.

The study released Friday examined more than 7,000 people across nine states and 187 hospitals, comparing those who were unvaccinated and had previously had the coronavirus in the last three to six months and those who were vaccinated over the same time frame. "


CBS: Vaccine offers more protection against COVID-19 than natural immunity, CDC study finds

"Unvaccinated people who had survived a previous COVID-19 infection were more than five times more likely to be reinfected with the virus compared to those who were fully vaccinated with the Pfizer or Moderna vaccines, ..."


CDC MMWR: Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021 | MMWR

"What is added by this report?

Among COVID-19–like illness hospitalizations among adults aged ≥18 years whose previous infection or vaccination occurred 90–179 days earlier, the adjusted odds of laboratory-confirmed COVID-19 among unvaccinated adults with previous SARS-CoV-2 infection were 5.49-fold higher than the odds among fully vaccinated recipients of an mRNA COVID-19 vaccine who had no previous documented infection (95% confidence interval = 2.75–10.99)."